Depression and inflammation -related problems have been another relevant study issues in recent years. Investigations about the pathophysiology of depression have corroborated that various factors demonstrate this relationship. For example, it has been determined that depression, most of the time, is accompanied by dissimilar inflammatory diseases; that stress generally stimulates proinflammatory pathways, and that antidepressant drugs normally decrease inflammatory responses.
The truth is that most people suffering from depression almost always have inflammatory diseases, cancer, diabetes, cardiovascular diseases, among many others. Another example that demonstrates this relationship is based on one in five individuals with cardiovascular conditions generally suffers from major depression disorder (TDM). To those people who are diagnosed with diabetes, often duplicate the risks of depressed. It also happens with those with the presence of autoimmune diseases, either lupus or arthritis, of which about 70% usually suffers depression eventually.
On the other hand, on those patients with cancer or with a diagnosis of previous autoimmune diseases, several studies have confirmed the increased risk of depression by approximately 45% of these people.
In this way, it is usually attributed high importance to inflammatory markers. During the inflammation process, the body releases cytokines, that is, the so -called protein molecules that emit a signal that leads to the action of the immune system, increasing and intensifying the activity of the cells involved in this mechanism of response at the level at level at level cellular or antibodies. However, the fact of significantly increasing inflammatory markers, they also increase depressive symptoms.
Some studies have also revealed that certain treatments based on immunomodulatory drugs in animals have increased the tendency to depression. Likewise, by indicating in humans treatments of diseases such as hepatitis C or harmful diseases in the blood, the risk of suffering from depression rises.
Similarly, it has been reported that other treatments such as the antitifoidea vaccine have caused depressive symptoms with brain alterations equivalent to those of the TDM.
According to the above, it can be said that depression may arise even when there is no inflammatory disease. However, numerous scientific studies have evidenced the close relationship between depressive symptoms and the increase in inflammatory markers, so it has been concluded that psychological stress does manage to stimulate inflammation.
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